PRDM16 enhances nuclear receptor-dependent transcription of the brown fat-specificUcp1gene through interactions with Mediator subunit MED1
نویسندگان
چکیده
منابع مشابه
The Mediator subunit MED1/TRAP220 is required for optimal glucocorticoid receptor-mediated transcription activation
The MED1/TRAP220 subunit of the Mediator plays a key role in facilitating ligand-dependent interactions of this multisubunit coactivator complex with nuclear receptors through their ligand binding domains. The isolated MED1/TRAP220 protein previously was shown to interact with glucocorticoid receptor (GR) in a ligand-dependent manner. However, the functional role of MED1/TRAP220, within the con...
متن کاملRegulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex.
Brown fat is a specialized tissue that can dissipate energy and counteract obesity through a pattern of gene expression that greatly increases mitochondrial content and uncoupled respiration. PRDM16 is a zinc-finger protein that controls brown fat determination by stimulating brown fat-selective gene expression, while suppressing the expression of genes selective for white fat cells. To determi...
متن کاملKey roles for MED1 LxxLL motifs in pubertal mammary gland development and luminal-cell differentiation.
Mediator recently has emerged as a central player in the direct transduction of signals from transcription factors to the general transcriptional machinery. In the case of nuclear receptors, in vitro studies have shown that the transcriptional coactivator function of the Mediator involves direct ligand-dependent interactions of the MED1 subunit, through its two classical LxxLL motifs, with the ...
متن کاملControlling Thermogenesis: Understanding the Role of PRDM16 in the Development and Function of Brown Fat
The alarming rise in the incidence of obesity found throughout the world has precipitated a need to look for novel methods to increase energy expenditure to counter weight gain. Recently it was discovered that adult humans possess a substantial mass of brown adipose tissue (BAT), a tissue that consumes stored lipid to produce heat. Although the primary physiologic role for BAT is to protect mam...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genes & Development
سال: 2015
ISSN: 0890-9369,1549-5477
DOI: 10.1101/gad.252809.114